![]() Values in excess of 150 mg/L or 300 mg/24 hr during pregnancy are usually associated with either pre-eclampsia or underlying renal disease. Meta-analysis has shown that the uPCR optimum threshold is between 0.3-0.35mg/mmol and this provides a sensitivity and specificity of above 0.75 ( 8). Standard reagent strips are used with further testing in the case of a positive result (24 hour sample testing and spot testing urine protein:creatinine ratio (uPCR) as per NICE and PRECOG guidelines) ( 6, 7). ![]() A recent audit of maternal deaths in the UK reported 19 deaths from pre-eclampsia and eclampsia during 2006-2008 indicating that the number of deaths from pre-eclampsia has not fallen since the 1991-1993 report ( 4).ĭiagnosing pre-eclampsia requires monitoring of blood pressure and proteinuria, typically by midwives at intermittent times during pregnancy, generally coinciding with antenatal visits ( 5). ![]() There are around 300-400 confirmed cases of pre-eclampsia in the UK every year ( 3). Pre-eclampsia can lead to eclampsia a serious condition with seizures and a high mortality rate (0.83). ![]() Protein leaking into the urine combined with high blood pressure defines pre-eclampsia, a condition affecting 2-8% of pregnancies in the UK ( 1, 2 ). Background, Current Practice and Advantages over Existing Technology ![]()
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